Gulfstream Daily Brief

Regulatory intelligence and policy · Issue 014

FDA opens year five of CMC pilot as EMA advances new guidance

FDA has opened year five of its CMC Development and Readiness Pilot, while EMA issued a clinical reflection paper for consultation and several veterinary regulatory updates.

By Scott Morvay, Founder September 21, 2026 Official sources linked

FDA

FDA announces year five of CMC readiness pilot

The agency outlined eligibility criteria and the process for requesting participation in a pilot supporting CMC readiness for CBER and CDER products with accelerated clinical development timelines.

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FDA

Orphan drug information collection moves to OMB review

FDA submitted a proposed orphan drug information collection to the Office of Management and Budget for review and clearance under the Paperwork Reduction Act.

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EMA

EMA opens consultation on systemic sclerosis clinical investigations

EMA published a draft reflection paper on the clinical investigation of medicinal products for treating systemic sclerosis, with consultation open.

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EMA

EMA adopts veterinary post approval change management Q&A

EMA adopted questions and answers on post approval change management protocols for veterinary medicinal products.

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EMA

Veterinary signal management revision enters consultation

EMA opened consultation on Revision 1 of its veterinary good pharmacovigilance practices module for signal management.

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MHRA

MHRA updates 2026 marketing authorisations record

MHRA published its record of marketing authorisations granted in 2026.

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Why this matters

The FDA pilot provides a defined route for eligible sponsors to seek increased agency communication on CMC readiness during accelerated development. In Europe, the open consultations give stakeholders an opportunity to examine emerging expectations, while the adopted veterinary Q&A provides a current reference for post approval change planning.

Scott Morvay

Founder, Gulfstream Intelligence

This brief provides general regulatory news and educational information. It is not legal or regulatory advice.